Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force Generation
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چکیده
منابع مشابه
Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully understood. We first characterize DC random motility (chemokinesis) on extracellular matrix proteins in the ...
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Endothelial cells are constantly exposed to fluid shear stresses that regulate vascular morphogenesis, homeostasis, and disease. The mechanical responses of endothelial cells to relatively high shear flow such as that characteristic of arterial circulation has been extensively studied. Much less is known about the responses of endothelial cells to slow shear flow such as that characteristic of ...
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BACKGROUND Adipose tissue is a readily available source of multipotent adult stem cells for use in tissue engineering/regenerative medicine. Various growth factors have been used to stimulate acquisition of endothelial characteristics by adipose-derived stem cells (ASC). Herein we study the effects of endothelial cell growth supplement (ECGS) and physiological shear force on the differentiation...
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When a cell adheres to an underlying substrate, it exerts traction forces on the substrate to enable migration. The cell traction forces (CTFs) are also essential for controlling cell shape and maintaining cellular homeostasis. As such, CTF plays a vital role in many fundamental biological processes including morphogenesis, angiogenesis, metastasis, and tissue wound healing. Thus, a close exami...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2004
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(04)74311-8